alport syndrome…

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male urinary system, hereditary nephritis, hematuria, nephropathy, deafness, hemorrhagic familial nephritis, hereditary deafness, nephropathy, alport syndrome, inherited disorder, x-linked, involving damage, kidney, blood, in the urine, families, loss of hearing, eye defects, alport syndrome is very similar to hereditary nephritis, nerve deafness, congenital eye abnormalities associated, alport syndrome, mutation, gene, collagen, disorder is uncommon, most often affects males, the genetic defect is typically found on the x chromosome, in women, disorder, minimal, no symptoms, women, transmit the gene, the disorder to children, woman has no symptoms, the disorder, in men, more severe, progress faster, disorder causes, chronic glomerulonephritis, destruction, the glomeruli, in the kidneys, initially, no symptoms, progressive destruction, the glomeruli causes, blood, in the urine, decreases the effectiveness, the kidney's filtering system, progressive loss of kidney function, accumulation of fluids, wastes, eventual progression to end-stage renal disease, esrd, at an early age, esrd, alport syndrome, develops between adolescence, age 40, risk factors include having a family history of alport syndrome, nephritis, end-stage renal disease in male relatives, hearing loss, age 30, bloody urine, glomerulonephritis, similar disorders, abnormal urine color, blood, in the urine, loss of hearing, common in males, decrease, loss of vision, common in males, cough, ankle, feet, leg swelling, swelling, swelling around the eyes, no symptoms symptoms of chronic renal failure, heart failure present, examination is nonspecific, except, blood, in the urine, minute amounts of blood, microscopic hematuria, present from birth in nearly all affected males, blood pressure elevated, examination, the eyes, fundus, posterior inner part of eye, lens changes, cataracts, lens protrusion, lenticonus, examination, the ears shows no structural changes, urinalysis shows blood, protein, abnormalities, bun, creatinine, elevated, red blood cell count, hematocrit, decrease, hematuria test is positive, audiometry, nerve deafness, renal biopsy shows chronic glomerulonephritis, the classical changes of alport syndrome, treatment goals include monitoring, controlling progression, treatment of symptoms, most important task is strict control of high blood pressure, treatment of chronic renal failure, become necessary, dietary modifications, fluid restriction, treatments, ultimately, chronic renal failure progresses to end-stage renal disease, requiring dialysis, transplantation, surgical repair of cataracts, cataract extraction, repair, the anterior lenticonus is possible, loss of hearing is likely to be permanent, counseling, education to increase coping skills, learning new skills lipreading, sign language of some benefit, hearing aids, young men, alport syndrome should use hearing protection in noisy environments, genetic counseling recommended, the inherited pattern, the disorder, in women, a normal life span, no manifestation except, blood, in the urine, women exhibit hypertension, edema, nerve deafness, a complication of pregnancy, in men, deafness, visual difficulties, renal failure, likely by age 50, chronic renal failure, end-stage renal disease, permanent deafness, decrease, loss of vision, symptoms indicating alport syndrome present, history of alport syndrome, children, urine output decreases, stops, a symptom of chronic renal failure, uncommon disorder is inherited, awareness of risk factors, family history, the disorder, allow the condition to be detected early.