charcot-marie-tooth disease, hereditary…

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central nervous system, progressive neuropathic, peroneal, muscular atrophy, hereditary peroneal nerve dysfunction, neuropathy, peroneal, hereditary, hereditary motor, sensory neuropathy, charcot-marie-tooth disease defines a group of inherited, slowly progressive disorders that result from progressive damage to nerves, symptoms include numbness, wasting of muscle tissue, in the feet, legs, hands, arms, charcot-marie-tooth diseases involve damage to nerves, neuropathy, from loss, the electrical insulation, myelin, around nerve fibers, all nerves, motor nerves, nerves that stimulate movement, most severely affected, nerves, in the legs, most severely, begin between mid-childhood, early adulthood, disorder is inherited, autosomal dominant, autosomal recessive, x-linked recessive inheritance patterns, at least 4 genes have been discovered to be the cause of this group of diseases, charcot-marie-tooth disease causes, destruction, the myelin sheath, people, in other people, central, axon, portion, the nerve cell degenerates, disorder most commonly affects the nerves, feet, legs, most significantly the peroneal nerve, damage is slowly progressive, beginning, foot drop, progressing up the legs, loss of muscle control, muscle tone, eventual loss of muscle mass, lack of nervous stimulation, muscles, weakness, decreased muscle strength, the hips, legs, feet, "slapping" gait, feet hit the floor hard, walking, foot drop, inability, hold foot horizontal, foot deformity, very high arch to feet, progressive leg deformity, "stork leg" appearance, loss of lower leg muscle mass skinny calves, numbness, in the foot, leg, similar symptoms, appear, in the arms, hands, a claw-like hand deformity, an examination by touch, reveal thickened nerve bundles under the skin, the legs, in the demyelinating form of charcot-marie-tooth disease, stretch reflexes, in the legs, absent, loss of muscle control, atrophy, in the foot, leg, lifting up the foot, dorsiflexion, toe-out movements, eversion, a muscle biopsy, nerve biopsy, confirm the diagnosis, nerve conduction tests, performed to distinguish axonal from demyelinating forms, the disorder, genetic testing is available, most forms, no known cure, charcot-marie-tooth disease, treatment is aimed at maximizing independence, orthopedic surgery, equipment, braces, orthopedic shoes, make it easier to walk, vocational counseling, occupational therapy, physical therapy appropriate, people to help maintain muscle strength, maximize independent functioning, charcot-marie-tooth disease is slowly progressive, eventually causing disability, not life-threatening, painful, numbness, in the area, progressive inability to walk, progressive weakness, injury to areas, decreased sensation, persistent weakness, decreased sensation, in the feet, legs, genetic counseling, testing is advised, strong family history.