chronic myelogenous leukemia, cml…

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bone marrow aspiration, auer rods, chronic myelocytic leukemia, microscopic view, chronic myelocytic leukemia, chronic myelocytic leukemia, antibodies, cml, chronic granulocytic leukemia, leukemia, chronic granulocytic (cml, chronic myelogenous leukemia, malignant cancer, the bone marrow, rapid growth, the blood-forming cells, myeloid precursors, bone marrow, peripheral blood, body tissues, occur in adults, middle-aged, children, cml affects 1 to 2 people per 100,000, accounts, 7% to 20% cases of leukemia, associated, a chromosome abnormality, the philadelphia chromosome, exposure to ionizing radiation is one possible trigger, chromosome abnormality, such exposure could occur, a nuclear disaster, from treatment of a previous cancer, thyroid cancer, hodgkin's lymphoma, vast majority of people treated, cancer, radiation do not go on to develop leukemia, takes many years to develop leukemia from this cause, chronic myelogenous leukemia is characterized by a chronic phase, last, have few, no symptoms, chronic phase, eventually, chronic phase progresses to a more dangerous "accelerated phase", the leukemia cells grow more quickly, acceleration, the disease associated, fever, infection, bone pain, an enlarged spleen, 5 years, in most people, disease then progresses to a "blast crisis", very high count of immature white blood cells, leukemia cells, blast phase, the leukemia is very difficult to treat, bleeding, infection, due to bone marrow failure, fatigue, weakness, excessive sweating, night sweats, low-grade fever, pressure under the left ribs, enlarged spleen, bleeding, bruising, sudden appearance of small red marks on the skin, petechiae, a physical examination often reveals an enlarged spleen, a cbc shows increased white blood cell count , a cbc differential is consistent, increased numbers of white blood cells, either mature, immature, depending on whether the disease, in the chronic, blast phase, additional signs, bone marrow aspiration, presence, the philadelphia chromosome, leukocyte alkaline phosphatase level, tests, vitamin b-12 level, uric acid, platelet count, treatment is aimed at reducing the growth, the leukemic cells, in the bone marrow, bring, a remission, no leukemia, good control, chronic phase, controlled, chemotherapy, an outpatient, interferon has been, achieve temporary remission, in 2001, fda approved a new drug, cml, imatinib, gleevec, is particularly effective, the disease has not responded to standard treatment, bone marrow transplant, drug works directly on the leukemic cells to slow growth, a bone marrow transplant preceded by high-dose chemotherapy, radiation therapy remains the standard treatment, not all people, cml, suitable candidates, transplantation, suitable donor, not known, present time which patients should receive a bone marrow transplant, the first treatment, who should receive gleevec, participation, medical study, "clinical trial", comparing these treatments appropriate, treatment recommendations, cml, changing quickly, new research findings, should discuss in detail, oncologist the advantages, disadvantages of each option, cancer support group, leukemia support group, curative treatment, disease is always fatal, on average, survival is 3 to 4 years, over half of those who receive a bone marrow transplant have long-term, disease-free survival, long-term survival after imatinib alone is not known, blast crisis, lead to complications of cml, infection, bleeding, fatigue, unexplained fever, kidney problems, chemotherapy, have serious side effects, depending on the drugs used, have symptoms suggestive of cml, have been diagnosed, cml, develop a fever higher than 100°f, chills, sore throat, cough, avoid exposure to radiation, .