familial dysbetalipoproteinemia…

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coronary artery disease, type iii hyperlipoproteinemia, deficient, defective apolipoprotein e, familial dysbetalipoproteinemia, inherited disorder, cholesterol, triglycerides, elevated, in the plasma, the blood, a gene defect that results in an accumulation of large lipoprotein particles that contain both cholesterol, triglyceride, disease is inherited in an autosomal recessive manner, traced to defects, in the gene, apolipoprotein e in many cases, disease, not evident by elevated blood levels, age of 20, atherosclerosis develops, in the coronary arteries, internal carotid arteries that supply blood, brain, abdominal aorta, its branches, condition predisposes people to coronary artery disease, peripheral vascular disease, condition is worsened by hypothyroidism, obesity, diabetes, risk factors, a family history of familial dysbetalipoproteinemia, coronary artery disease, yellow deposits of fatty material, in the skin, xanthomas, appear on the palm, the hand, sole, the foot, on tendons of knees, elbows, on the eyelids, early chest pain, angina, decreased blood flow to other parts, causing transient ischemic attacks, the brain, claudication, the legs, a physical exam revealing characteristic xanthomas, significantly increased remnants of vldl, chylomicrons, elevated total cholesterol, elevated triglycerides, increased liklihood of apoe2 genotype, defective apoe protein, atherosclerosis evident by angiogram, abnormal heart stress test, goal of treatment, control underlying conditions obesity, hypothyroidism, diabetes, make dysbetalipoproteinemia appear in people who would otherwise not have it, restriction of excess calories, reduction of saturated fats, cholesterol, significantly reduce cholesterol levels, high cholesterol, triglyceride levels persist, maximum dietary treatment, cholesterol lowering agents, started, nicotinic acid, niacin, clofibrate, statins, gemfibrozil, drugs, effectively reduced cholesterol, triglycerides in people affected, dysbetalipoproteinemia, individuals, form of hyperlipidemia have a significantly increased risk, coronary artery disease, most people show a significant reduction in lipid levels, premature myocardial infarction, heart attack, heart tissue death, strokes, blocked arteries, peripheral vascular disease, intermittent claudication, gangrene, the lower extremities, xanthomas, the skin, symptoms worsen, not improve, new symptoms develop, call a genetic counselor, family history of dysbetalipoproteinemia, screening, family members of people, familial dysbetalipoproteinemia, lead to early detection, early treatment, avoiding other risk factors, vascular disease, smoking, crucial to preventing early heart attacks, strokes, blocked blood vessels.