granuloma inguinale…

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skin layers, donovanosis, granuloma inguinale, sexually-transmitted disease that is rarely, surface destruction, granuloma formation, in the skin, subcutaneous tissue, granuloma inguinale, bacterial disease, organism calymmatobacterium granulomatis, disease is commonly found in tropical, subtropical areas southeast india, guyana, new guinea, occurs on occasion, in the southeast, approximately 100 cases reported per year, men, affected more than twice, women, most infections occuring in people aged 20-40 years, disease is seldom seen in children, elderly, thought that anal intercourse, rather than vaginal intercourse, frequent source of infection, 50% of infected men, women have lesions, in the anal area, beefy-red bump on the genitalia, perianal area that gradually eats away the skin, forms an elevated, beefy-red, velvety nodule, granulation tissue, nodules, painless, bleed, traumatized, gradual spreading, erosion, destruction of genital tissue, spread of disease, inguinal folds, legs meet the torso, depigmentation, loss of skin color, the genitals, surrounding skin, untreated disease results in mutilation, destruction, the genital tissue, in its early stages, difficult to differentiate granuloma inguinale from chancroid, later stages, granuloma inguinale, resemble advanced genital cancers, lymphogranuloma venereum, anogenital cutaneous amebiasis, classically, diagnosis of granuloma inguinale, genital lesions have been present, long time, have been progressively enlarging, serological tests that, detect syphilis, available only on a research basis, diagnosing granuloma inguinale, tests, scrapings, punch biopsy of lesion, tissue, microscopic examination, culture of tissue sample, difficult to, not routinely available, a complete cure of granuloma inguinale, fairly long treatment, most treatment courses run 3 weeks, lesions have completely healed, antibiotics used, tetracycline, doxycycline, sulfamethoxazole, gentamicin, streptomycin, ciprofloxacin, erythromycin, a follow-up examination is essential, the disease, reappear after an apparently successful cure, treating this disease early decreases the chances of tissue destruction, scarring, untreated disease, lead to complications, genital destruction, scarring, genital depigmentation, loss of skin color, permanent genital swelling from lymphatic scarring, sexual exposure to a person who is known to have granuloma inguinale, develop symptoms similar to those, safe sex practices, prevent the spread of granuloma inguinale, sexually-transmitted diseases, sexual contact, people living in tropical, subtropical climates increases the likelihood of exposure, keck jw, ulcerative lesions, clin fam pract, 2005 mar, 7(1), 13-30, rackel re, bope et, granuloma inguinale, conn's current therapy 2005, 57th ed, saunders, 859.