macroglobulinemia of waldenstrom…

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waldenstroms, antibodies, waldenstrom's macroglobulinemia, macroglobulinemia, primary, macroglobulinemia of waldenstrom, cancer, the b lymphocytes, a type of white blood cell, overproduction of monoclonal macroglobulin, igm antibody, characterized by overproduction of igm, blood to, become too thick, hyperviscosity, hyperviscosity newborn interferes, blood flow, small blood vessels, leads to many, disease occurs in 5 out of 100,000 people over 50 years old, fatigue, easy bruising, the skin, rash, nosebleeds, epistaxis, bleeding, the gums, unintentional weight loss, vision loss in one eye, headache, dizziness, blurred, decreased vision, mental status changes, peripheral neuropathy, in the nerves affecting the hands, feet, fingers, toes, ears, nose, manifested, numbness, tingling, burning pain, additional symptoms that associated, swollen glands, flank pain, bluish skin discoloration, fingers that change color upon pressure, a physical examination, reveal enlarged spleen, liver, lymph nodes, a retinal eye examination, examination, the eye, an ophthalmoscope, reveal enlarged, engorged, retinal veins, retinal bleeding, hemorrhages, a cbc shows low red blood cell count, platelet count, serum protein electrophoresis shows a monoclonal spike, increased amount, a monoclonal protein, a serum immunoelectrophoresis that shows an igm spike, a serum immunofixation that shows an igm spike, urine immunoelectrophoresis shows igm, a urine test, urine bence-jones proteins, quantitative, positive, bone lesions, a bone marrow examination, cells that resemble both lymphocytes, plasma cells, a blood chemistry shows evidence of renal disease, kidney disease, tests, 24-hour urine protein, total protein, serum globulin electrophoresis, positive immunofixation in urine, t, thymus derived, lymphocyte count, apheresis, in this case, plasmapheresis, plasma exchange, removing unwanted substances, blood, in macroglobulinemia, control the symptoms, hyperviscosity by removing, reducing the high concentration of igm, blood is withdrawn, person, in the same way, blood donation, blood is passed, a cell separator that removes the plasma, fluid portion, contains the antibodies, formed elements, blood cells, reconstituted, a plasma substitute, donated plasma, reconstituted blood is then returned, blood transfusion, an acute procedure designed to quickly control symptoms, drug therapy, leukeran, alkeran, cytoxan, corticosteroids, anemia, deficient number of red blood cells, leukopenia, deficient number of white blood cells, thrombocytopenia, deficient number of platelets, later stages, require the use of packed red cell transfusions, antibiotics, platelet transfusions, median, average, survival, 5 years, people, disorder chronic, few symptoms, slow progression, vision impairment, gastrointestinal bleeding, alterations in mental status possibly progressing to coma, congestive heart failure, symptoms of this disorder develop.