mccune-albright syndrome…

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anterior skeletal anatomy, polyostotic fibrous dysplasia, mccune-albright syndrome, genetic disease affecting the bones, pigmentation, the skin, hormonal problems, premature sexual development, hallmark of mccune-albright syndrome is premature puberty in girls, menstrual periods, in early childhood, the appearance of breast, pubic hair development, occur, early sexual development, occur in boys, common, in girls, children have abnormal fibrous dysplasia, abnormal fibrous development, bone, lead to fractures, deformities, abnormal x-rays, abnormal bone growth, in the skull, lead to blindness, deafness, due to "pinched" nerves, deformities, appear, in the facial bones, cosmetic problems, children have cafe-au-lait spots on skin, present from birth, mccune-albright syndrome, mutations, in the gnas1 gene, mosaicism, meaning that the abnormal gene is present, fraction, the patient's cells, disease is not inherited, sporadic, that a new mutation, the dna occurs, in the womb, the patient, mutation is not passed on to any children the patient later has, irregular, patchy cafe-au-lait spots, on the back, vaginal bleeding, first menstruation, at a very early age, premature puberty, early breast development, early pubic, armpit hair development, patients get more broken bones, a form of gigantism, overgrowth, excess hormones, a physical examination, signs of, hyperthyroidism, adrenal abnormalities, acromegaly, cafe-au-lait spots, the skin, signs of hyperthyroidism, hyperparathyroidism, excess adrenal hormones, excess blood prolactin, growth hormone, x-rays show fibrous dysplasia, multiple bones, an mri, the head, a type of tumor, an adenoma, in the pituitary gland, genetic testing available, the gnas1 gene, not a specific treatment, mccune-albright syndrome, drugs that inhibit estrogen production, testolactone, have been tried, success, adrenal abnormalities, cushing's syndrome, treated by surgery to remove the adrenal glands, gigantism, pituitary adenoma, require treatment, hormone inhibitors, surgery, life span is relatively normal, repeated episodes of broken bones, cosmetic problems resulting from bone abnormalities, blindness, deafness, tumors, premature puberty, osteitis fibrosa cystica, child develops evidence of premature puberty, the expected age, has other symptoms suggestive of mccune-albright syndrome, genetic counseling, possibly genetic testing, recommended disease is diagnosed.