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metyrapone test
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what the risks are
metyrapone test measures the ability, the pituitary gland to secrete acth in response to decreased serum cortisol, two different types of metyrapone tests, overnight test, a single dose of metyrapone is given at 11 p, m, blood is drawn at 8 a, m, measurement of serum cortisol, another hormone, 11-deoxycortisol, second form, metyrapone is given 6 times a day, a 24-hour urine sample is collected, measurement of 17-ohcs, a metabolic product of cortisol, blood samples, serum cortisol, 11-deoxycortisol, drawn,
health care provider, advise to temporarily discontinue drugs, affect the test, drugs, affect metyrapone test measurements include chlorpromazine, corticosteroids, birth control pills, estrogen-containing medications, cause false-positive results, infants, children, test depends on child's age, level of trust, prepare child, infant test, procedure preparation, birth to 1 year, toddler test, procedure preparation, 1 to 3 years, preschooler test, procedure preparation, 3 to 6 years, schoolage test, procedure preparation, 6 to 12 years, adolescent test, procedure preparation, 12 to 18 years, the needle is inserted to draw blood, feel moderate pain, others feel only a prick, stinging sensation, some throbbing,
test is used, whether the pituitary gland is functioning properly, metyrapone inhibits an enzyme, steroid 11-beta hydroxylase, involved, in the construction, the steroid hormone cortisol, converts 11-deoxycortisol to cortisol, resulting fall in serum cortisol levels, stimulates the pituitary to secrete acth, attempts to stimulate the adrenal cortex to make cortisol, the enzyme is inhibited, 11-deoxycortisol builds up, in the blood, urine,
blood, 11-deoxycortisol increased to more than 7 mcg/dl, cortisol less than 10 mcg/dl, 24-hour urine, baseline excretion of urinary 17-ohcs more than doubled, normal value ranges, among different laboratories, mcg/dl = micrograms per deciliter
test useful in distinguishing between the different types of cushing's syndrome, help diagnose adrenal insufficiency, excessive bleeding, fainting, feeling lightheaded, hematoma, blood accumulating under the skin, infection, a slight risk, the skin is broken, multiple punctures to locate veins,
not applicable.
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