paget's disease…

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x-ray, osteitis deformans, paget's disease, metabolic bone disease that involves bone destruction, regrowth which results in deformity, paget's disease, theories, early viral infection, genetic causes, disease occurs worldwide, more common in europe, australia, new zealand, where it, 5%, the elderly population, disease is characterized, excessive breakdown of bone tissue, followed by abnormal bone formation, new bone is structurally enlarged, weakened, filled, new blood vessels, localize to one, two areas, the skeleton, become widespread, bones, the pelvis, leg, spine, arm, collar bone, involved, effect on the skull, enlarge head size, hearing loss, cranial nerves, damaged by the bone growth, bone pain, severe, persistent, joint pain, joint stiffness, headache, bowing, the legs, warmth of skin overlying affected bone, fracture, neck pain, reduced height, hearing loss, most patients have no symptoms, indicate paget's disease, a bone x-ray that shows increased bone density, thickening, bowing, overgrowth, a bone scan, elevated serum alkaline phosphatase, elevated markers of bone breakdown, instance, n-telopeptide, tests, serum calcium, alp, alkaline phosphatase, isoenzyme, drug therapy is aimed at suppressing bone breakdown, currently, several classes of medications that inhibit bone resorption, in the treatment of paget's disease, bisphosphonates, calcitonin, plicamycin, biphosphonates, the first-line treatment, medications, etidronate, didronel, alendronate, fosamax, pamidronate, aredia, tiludronate, skelid, risedronate, actonel, calcitonin class includes intranasal, miacalcin, subcutaneous, calcimar, forms, plicamycin, mitrhracin, analgesics, nonsteroidal anti-inflammatory medications, nsaids, pain, localized paget's disease, no treatment, no symptoms, no evidence of active disease, orthopedic surgery required, a specific deformity in severe cases, paget foundation, 120 wall st, suite 1602, new york, ny 10005-4001, toll-free, 800-23-paget, ph, 212-509-5335, website, paget, e-mail, pagetfdn@aol, com, disease activity, generally be, controlled, current medications, malignant changes of bone occur in less than 1% of people affected, deafness, spinal stenosis, deformities, bone fractures, paraplegia, cardiac failure, symptoms of paget's disease develop.