paroxysmal cold hemoglobinuria, pch…

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blood cells, pch, pch, rare blood disorder involving antibody formation that destroys red blood cells after an affected person is exposed, cold, paroxysmal cold hemoglobinuria, condition in which antibodies, formed that attack a specific type of blood cell, antibodies bind, attach, to red blood cells, to a cell-lysing, destroying)protein, in the blood, complement, occurs, in the cold, affects only the hands, feet, cell destruction occurs, the blood cells, become rewarmed by circulating, the cells, destroyed, hemoglobin is released, blood, passed, in the urine, disease has been associated, secondary syphilis, tertiary syphilis, infections, viruses, bacteria, recovery, attacks is very quick, not experience symptoms between episodes, attacks end, the affected cells, no longer in circulation, risk factors, viral infection, syphilis, disorder is rare, chills, fever, back pain, leg pain, abdominal pain, headache, general discomfort, uneasiness, ill feeling, malaise, blood, in the urine, red urine, positive donath-landsteiner test, serum hemoglobin increased, attacks, urine hemoglobin increased, cbc shows anemia, coombs test is negative, bilirubin is elevated, ldh is elevated, no specific treatment exists, syphilis respond to treatment, the underlying disorder, many cases, resolve, people, attacks, occur repeatedly, many years, recurrence of attacks, severe anemia, kidney failure, call health provider, symptoms of this disorder develop, to rule out other causes, treatment is needed, people known to have this disease, prevent future attacks by limiting exposure, cold.