pemphigus vulgaris…

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pemphigus, vulgaris on the back, pemphigus, vulgaris, lesions, in the mouth, pemphigus vulgaris, autoimmune skin disorder characterized by blistering, the skin, mucous membrane, pemphigus involves blistering, the outer, epidermal, layer, the skin, mucous membranes, an autoimmune disorder, the immune system produces antibodies against specific proteins, in the skin, mucous membrane, antibodies produce a reaction, leads to a separation of epidermal cells, acantholysis, exact cause, the development of antibodies against the body's own tissues, autoantibodies, pemphigus appears in reaction to medications, this is rare, pemphigus a side effect of ace inhibitors, elanapril, chelating agents, penicillamine, pemphigus is uncommon, occurs exclusively in middle-aged, older people of all races, ethnic groups, one-half, the cases of pemphigus vulgaris begin, blisters, in the mouth, followed by skin blisters, blisters, bullae, relatively asymptomatic, the lesions, become widespread, complications develop rapidly, debilitating, fatal, skin lesions, recurrent, relapsing, blistering, flaccid, mouth, skin ulcers, draining, oozing, crusting, located on the mucous membrane, the mouth, located on the scalp, trunk, skin areas, spreading to other skin areas, peeling superficially, detaching, nikolsky's sign is positive, the surface of uninvolved skin is rubbed laterally, a cotton swab, finger, skin separates, a skin lesion biopsy shows acantholysis, an examination, the biopsy tissue, immunofluorescence confirms pemphigus, tzanck test of a smear, base of a blister shows acantholysis, severe cases of pemphigus, treated similarly to severe burns, require hospitalization, care, burn unit, intensive care unit, treatment is aimed at reducing symptoms, preventing complications, intravenous fluids, electrolytes, proteins required, mouth ulcers, severe, mean intravenous feeding is needed, anesthetic mouth lozenges, reduce the pain of mild to moderate mouth ulcers, antibiotics, antifungal medications appropriate to control, prevent infections, systemic therapy, is required to control pemphigus, side effects from systemic therapy, a major complication, treatment includes corticosteroids, medications containing gold, medications that suppress the immune system, azathioprine, methotrexate, plasmapheresis, antibody-containing plasma is removed, blood, replaced, intravenous fluids, donated plasma, used in addition, systemic medications to reduce the amount, antibodies, in the bloodstream, localized treatment of ulcers, blisters, soothing, drying lotions, wet dressings, similar measures, not treated, pemphigus vulgaris, fatal, generalized infection, most frequent cause of death, disorder tends to be chronic side effects of treatment severe, disabling, side effects of systemic medications, secondary bacterial, viral, fungal infection, the skin, spread of infection, the bloodstream, sepsis, loss of extensive amounts of body fluids, loss of electrolytes, electrolyte disturbances, unexplained blisters should always be examined by physician, have been treated, pemphigus vulgaris, develop any, fever, general ill feeling, chills, muscle aches, joint aches, new blisters, ulcers.