primary myelofibrosis…

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myelofibrosis, idiopathic myelofibrosis, myeloid metaplasia, agnogenic myeloid metaplasia, primary myelofibrosis, the bone marrow, the marrow is replaced by fibrous, scar, tissue, in primary myelofibrosis, a progressive scarring, fibrosis, the bone marrow occurs, blood formation to take place in sites other than the bone marrow, liver, spleen, causing enlargement of these organs, develops slowly, in people over 50 years old, leads to progressive bone marrow failure, severe anemia, low platelet count leads to easy bleeding, spleen enlargement continues, disease gets progressively worse risk factors, unknown, fatigue, abdominal fullness related to an enlarged spleen, easy bleeding, bone pain, pallor, paleness, shortness of breath on exertion, bruising, increased susceptibility to infection, physical examination shows an enlarged spleen, in the disease, an enlarged liver, an examination, the blood shows teardrop-shaped red blood cells, white blood cell count is variable, platelet count is variable, bone marrow biopsy performed to rule out other causes, cbc, complete blood count, a low red blood cell count, no specific treatment, primary myelofibrosis, blood transfusions, anemia, recombinant erythropoietin, androgens, stimulate red blood cell production, beneficial, a splenectomy, removal, the spleen, help enlarged size, the spleen causes, radiation, chemotherapy, in young people, bone marrow transplants appear to improve the outlook, average survival of people, primary myelofibrosis, 5 years, survive, decades, end stages, myelofibrosis, wasting, debilitating illness, liver failure, acute myelogenous leukemia, symptoms of this disorder develop, uncontrolled bleeding, shortness of breath, jaundice, progressive confusion, symptoms that indicate a need, urgent, emergency care, no known prevention.