 prostate cancer, genetic, markers…
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male reproductive anatomy, prostate cancer, psa blood test, amacr
second leading cause of cancer death in american men is prostate cancer, lung cancer, in 2002, doctors told an estimated 189,000 men that they have the potentially fatal disease, in an effort to lower these numbers, in the future, researchers, investigating many possible markers, prostate cancer, markers, one day help identify men at higher risk, a gene, amacr, x-methylacyl-coa racemase, appears to trigger production of a specific protein found only in cancer cells, gene has been identified, a potential prostate cancer marker by several groups of researchers, findings suggest that amacr could eventually help pinpoint early prostate cancer, enhance diagnostic accuracy, in theory, a blood test, the gene could reduce the need, needle biopsies, the prostate, "since amacr enzymatic activity is not found in most normal tissues, could be used to…develop molecular probes, noninvasive detection of prostate cancer", says june luo, ph, d, lead author of a johns hopkins study, protein produced by amacr helps the body metabolize certain fatty acids, found in dairy products, beef, researchers caution that the link, between an overexpression of amacr, a man's diet warrants further study, another area of active research, proteomics, proteomics identifies small amounts of proteins, peptides, small molecules, patient's blood serum using a technique, mass spectrometry, recent evidence indicates that patterns of these molecules, highly specific, sensitive, variety of cancers, prostate, ovarian, many others, one possible advantage of this approach would be to identify patients, cancer, needing to, a biopsy, a way to better determine who should undergo a biopsy, interest in proteomics has risen partly due, completion, the human genome project, humans, contain, few, 30,000 genes, far fewer than had been predicted, finding has come the realization that cancer largely involves protein abnormalities, abnormal structure, location, in the cell, synthesis, turnover, interactions, proteins, molecules, modifications the addition of phosphate groups, phosphorylation, sugar residues, glycosylation, proteomics is still, in the investigational stage, not routinely used, diagnostic, treatment decisions at this time, expected that advances in this field over the next several years might have relevant, important clinical applications, meantime, medical community is deeply divided over the issue of screening, prostate cancer, at this time, no evidence that detecting prostate cancer early saves lives, that the harm, subsequent procedures surgery, radiation, hormonal therapy, chemotherapy, outweigh any possible benefit.
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