syphilis, tertiary…

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late-stage syphilis, antibodies, late syphilis, tertiary syphilis, tertiary syphilis, late phase, the sexually transmitted disease syphilis, spirochete treponema pallidum, tertiary syphilis, follow the initial infection, primary syphilis, by 3 to 15 years, secondary syphilis, stage that precedes tertiary syphilis, primary syphilis is not treated, in tertiary syphilis, spirochetes have continued to reproduce, pockets of damage accumulate in various tissues the bones, skin, nervous tissue, heart, arteries, lesions, gummas, very destructive, lesions, in the central nervous system produce neurological disease, neurosyphilis, tabes dorsalis, general paresis, optic atrophy, lesions, the heart, heart valves, aorta, lead to aneurysms, valvular heart disease, aortitis, tertiary syphilis is less frequently seen today than, early detection, adequate treatment, incidence of tertiary syphilis is approximately 5 per 100,000 individuals annually, in the us, symptoms of tertiary syphilis depend on which organ systems have been affected, vary widely, difficult to diagnose, in individuals, tertiary syphilis the primary, secondary stages of syphilis, have been long forgotten, medical findings of aortic aneurysms, neurological problems, require astute diagnostic ability to link them to syphilis, the symptomatic problems, listed below, infiltrative tumors of skin, bones, liver, gumma, cardiovascular syphilis which affects the aorta, aneurysms, valve disease, central nervous system disorders, neurosyphilis, vdrl, rpr blood tests, confirmatory blood tests, fta-abs, fluorescent treponemal antibody test, spinal fluid examination in neurosyphilis shows signs of meningitis, treatment of syphilis is determined by the length of time the person has been infected, primary, secondary, latent syphilis of less than 1 year duration is treated, benzathine penicillin 2.4 million units injected into a muscle, im, a single dose, doxycycline 100 mg by mouth twice per day, 2 weeks, tetracycline 500 mg by mouth 4 times per day, 2 weeks, erythromycin 500 mg by mouth 4 times per day, 2 weeks, ceftriaxone 250 mg im, intramuscular injection, daily, 10 days, treatment of syphilis of greater than 1 year duration, benzathine penicillin 2.4 million units im weekly, 3 weeks, doxycycline 100 mg by mouth twice per day, 30 days, tetracycline 500 mg by mouth twice per day, 30 days, treatment of neurosyphilis, aqueous penicillin g 12 to 24 million units injected into a vein, iv, daily, 10 days followed by benzathine penicillin 2.4 million units once a week, 3 weeks, procaine penicillin 2.4 million units im daily given, oral probenecid 500 mg 4 times per day, 10 days, to treat syphilis, pregnancy, penicillin, the only drug of choice, tetracycline cannot be used, toxicity, fetus, erythromycin, fail, prevent congenital syphilis, in the fetus, penicillin-allergic individuals, desensitized, penicillin, several hours following treatment of early stages of syphilis, individuals, undergo a febrile reaction, jarisch-herxheimer reaction, thought to be, release, circulation of material from dead, dying spirochetes, symptoms of this reaction, fever, chills, headache, nausea, general feeling of ill, malaise, generalized joint aches, arthralgia, generalized muscle aches, myalgia, disappear, follow-up blood tests must be done at 3, 24 months to ensure that the infection has been eliminated, individuals, primary, secondary syphilis should abstain from sex, they have been treated, syphilis is extremely contagious, in the primary, secondary stages, late syphilis permanently disabling, lead to death, cardiovascular syphilis, aneurysms, valvular heart disease, neurosyphilis, tabes dorsalis, general paresis, optic nerve atrophy, optic neuritis, untreated syphilis, result in serious health problems, imperative that inform physician, the possibility of having had syphilis previously, was many years ago, multiple, unknown sex partners, partners who, involved in any high-risk sexual practices, at risk, acquiring sexually transmitted diseases, stds, individuals who recognize that they, at risk have taken the first step toward prevention, total abstinence, way to completely avoid the possibility of infection, a sexually transmitted disease, monogamous sex, a healthy partner is lower risk, protected sex using condoms also dramatically reduces risk, condoms act, a barrier, transmission of infectious organisms, pathogens, used in any, all situations that could be considered risky, syphilis, reportable disease, infection must be reported by health care professionals to public health authorities, information acquired from reporting helps public health investigators identify, locate, treat infected sexual contacts, helps, prevent continued spread of disease.