systemic lupus erythematosus…

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systemic lupus erythematosus, lupus, discoid, view of lesions on the chest, lupus, discoid on a child's face, systemic lupus erythematosus rash on the face, lupus, discoid on the face, antibodies, disseminated lupus erythematosus, sle, lupus, lupus erythematosus, systemic lupus erythematosus, sle, chronic, inflammatory autoimmune disorder, affect the skin, joints, kidneys, organs, immune system controls the body's defenses against infection, in sle, autoimmune diseases, defenses, turned against the body, rogue immune cells attack tissues, antibodies produced, react against the body's blood cells, organs, tissues, lead immune cells to attack the affected systems, producing a chronic, long-term, mechanism, autoimmune diseases is not fully known, many researchers suspect it occurs following infection, an organism that looks similar to particular proteins, later mistaken, the organism, wrongly targeted, attack, disease affects 9 times, many women, men, occur at any age, appears most often in people between the ages of 10, 50 years, sle, certain drugs, occurs, drug-induced lupus erythematosus, reversible, the medication is stopped, course, a mild episodic illness to a severe fatal disease, symptoms also vary widely, particular individual over time, characterized by periods of remission, exacerbation, at its onset, one organ system involved, additional organs, become involved later, following organ system manifestations, manifestations, muscles and bones, sle have joint pain, most develop arthritis, frequently affected joints, the fingers, hands, wrists, knees, death of bone tissue, in the hips, shoulders, frequently a cause of pain in those areas, skin, a "butterfly" rash over the cheeks, bridge, the nose affects, half of those, sle, rash, worsened by sunlight, a more diffuse rash, appear on other body parts, exposed, sun, skin lesions, nodules, kidneys, sle have deposits of antibodies, the cells, glomeruli, the kidneys, less than 50% have lupus nephritis, defined by persistent inflammation, irritation, swelling, kidney, patients, eventually develop kidney failure, require dialysis, kidney transplantation, nervous system, nerve disorders, affect up to 25% of those, sle, mild mental problems, the most common symptom, the brain, spinal cord, nervous system, seizures, psychosis, organic brain syndrome, headaches, the nervous system disorders, blood, blood disorders, affect up to 85% of those, sle, venous, arterial blood clots, form, strokes, pulmonary embolism, pregnancy loss, predisposition to blood clots, less commonly bleeding, occurs, due to antibodies against lipids involved in blood clotting, anti-phospholipid antibody syndrome, aps, lupus anticoagulant, platelets, decreased, bleeding, clotting problems, anemia of chronic disease often develops at some point, in the course sle, heart, inflammation of various parts, the heart, pericarditis, endocarditis, myocarditis, chest pain, arrhythmias, result from these conditions, lungs, pleurisy, an inflammation, the lining, the lung, pleural effusions, a fluid collection between the lung, its lining, a result of sle, chest pain, shortness of breath, frequently results of these disorders, african americans, asians, affected more often than people from other races, fever, fatigue, general discomfort, uneasiness, ill feeling, malaise, weight loss, skin rash, a "butterfly" rash, aggravated by sunlight, sensitivity to sunlight, joint pain, swelling, arthritis, swollen glands, muscle aches, nausea, vomiting, pleuritic chest pain, seizures, psychosis, additional symptoms that associated, blood, in the urine, coughing up blood, nosebleed, swallowing difficulty, skin color is patchy, red spots on skin, fingers that change color upon pressure, cold, numbness, tingling, mouth sores, hair loss, abdominal pain, visual disturbance, diagnosis of sle, based upon, at least four out of eltypical characteristics, disease manifestations, antinuclear antibody, ana, panel, anti-dna, anti-smith antibodies, the latter two tests generally positive in lupus alone, characteristic skin rash, lesions, chest x-ray showing pleuritis, pericarditis, listening, chest, a stethoscope to reveal heart friction rub, pleural friction rub, urinalysis to show blood, casts, protein, in the urine, cbc showing a decrease, cell types, kidney biopsy, neurological examination, tests, wbc count, serum globulin electrophoresis, rheumatoid factor, urine protein, serum protein electrophoresis, mononucleosis spot test, esr, cryoglobulins, coombs' test, direct, complement component 3, c3, complement, antithyroid microsomal antibody, antithyroglobulin antibody, antimitochondrial antibody, anti-smooth muscle antibody, disease has multiple symptoms, variable severity, determines individual treatment, no cure, sle, mild disease, rash, headaches, fever, arthritis, pleurisy, pericarditis, little therapy, nonsteroidal anti-inflammatory medications, nsaids, treat arthritis, pleurisy, corticosteroid creams, treat skin rashes, antimalarial drugs, hydroxychloroquine, low dose corticosteroids, used, skin, arthritis symptoms, sensitivity to light is treated by protective clothing, sunglasses, sunscreen, severe, life-threatening manifestations, hemolytic anemia, extensive heart, lung involvement, kidney disease, central nervous system involvement, treatment by both rheumatologists, specialists, in the specific area, corticosteroids, medications to suppress the immune system, prescribed to control the various symptoms, health care professionals, use cytotoxic drugs, drugs that block cell growth, to treat people who, not have a good response to corticosteroids, dependent on high doses of corticosteroids, lupus resources, sle has improved over recent years, many of those affected have mild illness, women, sle who, become pregnant, able to carry the pregnancy safely to term, deliver normal infants, provided severe kidney, heart disease is not present, sle is managed, presence of anti-phospholipid antibodies, increase the possibility of pregnancy loss, 10-year survival rate, lupus patients exceeds 85%, severe involvement, the brain, lungs, heart, kidney have the worst prognosis in terms of overall survival, disability, infection, kidney failure, thrombocytopenia, hemolytic anemia, myocarditis, seizures, symptoms of sle, have sle, symptoms worsen, new symptoms develop, harris ed, budd rc, genovese mc, firestein gs, sargent js, sledge cb, kelley's textbook of rheumatology, 7th ed, wb saunders, noble j, textbook of primary care medicine, 3rd ed, mosby, 2001.