thrombotic thrombocytopenic purpura…

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blood cells, ttp, ttp, blood disorder characterized by low platelets, low red blood cell count, premature breakdown, the cells, abnormalities in kidney function, neurological, nervous system, abnormalities, a similar condition is hemolytic-uremic syndrome, disease, a deficiency in an enzyme, a type of protein, the von willebrand factor cleaving protease, adamts13, loss of this enzyme results in large complexes of von willbrand factor circulating, in the blood, in turn causes, platelet clumping, red blood cell destruction, most cases have no known cause, cases related to a deficiency of adamts13 at birth, cancer, chemotherapy, hiv infection, hormone replacement therapy, estrogens, a number of medications in common use, ticlopidine, clopidogrel, cyclosporine a, fever, weakness, easy fatigue, pallor, shortness of breath on exertion, heart rate over 100 per minute, purpura, purplish discolorations, in the skin produced by small bleeding vessels near the surface, the skin, bleeding, skin, mucus membranes, headache, confusion, speech changes, alterations in consciousness, yellowish color, skin, jaundice, platelet count is low, cbc shows anemia, bilirubin is high, blood smear shows schistocytes, fragmented blood cells, urinalysis shows protein, microscopic blood particles, creatinine level is high, mucus membrane biopsy reveals platelet clots in small blood vessels, plasmapheresis, plasma exchange, remove unwanted substances, blood, large von willebran protein complexes, to replace the missing protease, blood is withdrawn, blood donation, plasma portion, the blood is passed, a cell separator, remaining portion, the blood is saved, reconstituted, fresh plasma, returned, a blood transfusion, in thrombotic thrombocytopenic purpura, treatment is repeated daily, blood tests show improvement, not respond to this treatment, have frequent recurrences, require the removal, the spleen, corticosteroids, immune suppression, plasmapheresis has improved the outcome of this disease so that 80-90% of patients now recover completely, fatalities still occur, relapses, remaining cases, become chronic, long-term, kidney failure, hemorrhage, stroke, unusual, unexplained bleeding occurs, the specific cause, specific prevention is also unknown.