transfusion reaction…

Medical experts recommend this detailed explanation.

[ Find Organization | Index Page ]

surface proteins causing rejection, blood transfusion reaction, transfusion reaction, complication of blood transfusion where there, immune response against the transfused blood cells, components, the transfusion, immune response, protects the body from potentially harmful substances, antigens, trigger multiple responses, production of antibodies, immunoglobulins, molecules that attach to a specific antigen, aid in its destruction, sensitized lymphocytes that recognize a particular antigen, destroy it, immune system, distinguish its own blood cells from other cells, foreign proteins, antigens, produce an immune response, surface of red blood cells contain several proteins, identified by the body, antigens, german pathologist, karl landsteiner, identified 2 of these antigenic proteins, a, b, blood is classified according, presence of these antigens, resulting in blood types a, b, ab, contains both antigens, o, contains neither antigen, blood plasma contains antibodies against the opposite antigen, type a blood, has antibodies against the b antigen, in 1940, dr, landsteiner discovered another group of antigens, were named rhesus factors, rh factors, they were discovered, experiments on rhesus monkeys, rhesus factors in blood, "rh positive", persons, the factors, "rh negative", rh negative persons form antibodies against the rh factor, exposed to rh positive blood, of major importance in an rh negative mother who is pregnant, an rh positive baby, antigens, besides abo, rh antigens, presence of antibodies against blood antigens results in blood group compatibility, incompatibility, transfusion of blood between compatible groups, o+ to o+, causes, no problem, blood transfusion between incompatible groups, a+ to o-, an immune response against the cells carrying the antigen, resulting in transfusion reaction, immune system attacks the donated blood cells, causing them to burst, serious symptoms, kidney failure, shock, antigens also occur on other blood components, white blood cells, platelets, plasma proteins, components also cause a similar type of transfusion reaction, antibodies, in the transfused blood, bind, patient's own blood cells, causing a reaction, all blood is screened, modern lab methods, redundant checks have helped make transfusion reactions extremely rare, fever, chills, rash, flank pain, back pain, bloody urine, fainting, dizziness, symptoms of transfusion reaction, appear, transfusion, develop after several days, delayed reaction, remain mild, progress to kidney failure, delayed anemia, shock, tests, rbc count, hemoglobin, serum, hemoglobin, hematocrit, haptoglobin, fibrin degradation products, coombs' test, indirect, coombs' test, direct, cbc, bilirubin, goal of treatment, prevent, treat severe effects of transfusion reaction, symptoms occur, transfusion, transfusion is stopped, blood samples, person receiving the transfusion, from remaining donor blood, tested to confirm that symptoms, transfusion reaction, mild symptoms treated according, symptom, antihistamines diphenhydramine, reduce itching, rash, acetaminophen recommended to reduce fever, discomfort, corticosteroids prednisone, dexamethasone given to reduce the immune response, intravenous fluids, various medications, treat/prevent kidney failure, shock, depending on the severity, the reaction, disappear completely, severe, life threatening, discomfort, anemia, acute kidney failure, shock, lung disfunction, a blood transfusion is planned, previous transfusion reaction has occurred, typing of donated blood into abo, rh groups has reduced the risk of transfusion reaction, prior to a transfusion, blood, crossmatched to further confirm that the blood is compatible, a small amount, donor blood is mixed, a small amount, recipient blood, mixture is examined under a microscope, signs of antibody reaction.