... of unmetabolized EG, preventing metabolism of EG, and correcting the metabolic acidosis that occurs with EG metabolism. Further absorption of EG is prevented by induction of emesis or gastric lavage (or both) followed by administration of activated charcoal and sodium sulfate within 1-2 hr of ingestion. Once absorption has occurred, excretion of EG is increased by fluid therapy designed to correct dehydration and increase urine production. To prevent metabolism of EG, the activity of alcohol dehydrogenase is decreased by direct inactivation or by competitive inhibition. 4-Methylpyrazole (4-MP, fomepizole) effectively inactivates alcohol dehydrogenase in dogs without the side effects of ethanol and is the treatment of choice. The dose of 4-MP (5 %solution [50 mg / mL ]) is 20 mg / kg body wt, IV, initially, followed by 15 mg / kg, IV, at 12 and 24 hr, and 5 mg / kg, IV, at 36 hr. Commercial formulations of 4-MP are available. In cats, 4-MP is ineffective at the canine dosage, and ethanol, a competitive inhibitor of alcohol dehydrogenase ...